This sounds fun!
Marcone could still be the one from the originial universe, but Harry's just moved to Chicago, hears about some infamous artifact/antique/etc that's just been acquired by some rich guy. Whatever it is, is mega-cursed, the poor sap who's got it needs help; so ... the owner's with the mob. The previous bosses (the Vargassis)weren't that great. How bad can this Marcone guy be?